Separating Database

Hi, I do have two databases from two locations with replication enabled but now we decided to have these two databases completely separated from each other. Removing or disabling replication is easy but I am now worried about the apps that depend on these databases. Database A, table A will have some additional columns compared to Database B, table A. 
My question is, do I need to separate my app as well or just create separate classes for each database? 
Regards